Traceless and multifunctional linkers for the generation
Linkers for Antibody Drug Conjugates: Current Role and May 31, 2016 NJ BIO — Introduction to Antibody-Drug Conjugates The most popular linker is the protease cleavable linker that contains a valine-citrulline-para-aminobenzyl-carbamate moiety (vc-PABC). 10 This is a traceless linker that allows the release of amine containing cytotoxins. Many di-, tri-, and tetra-peptide sequences are cleaved by proteases and changing the sequence can facilitate the synthesis
Application of an almost traceless linker in the synthesis
A traceless linker strategy for the solid-supported synthesis of 5-benzoylbenzimidazoles has been developed. springer. We find that the two theories are physically equivalent when the matter sources of the gravitational field have a traceless energy-momentum tensor, but otherwise remain distinct.
May 31, 2016
A facile solid-phase synthesis of 3,4,6-trisubstituted-2-pyridones using sodium benzenesulfinate as a traceless linker. Tetrahedron Letters 2004, 45 (35) , 6545-6547. DOI: 10.1016/j.tetlet.2004.07.051. C GIL. Traceless and multifunctional linkers for the generation of small molecules on solid supports. A traceless photocleavable linker for the automated glycan